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A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. 16 issue of the British Medical Journal, Padwal's team found that long-term users of weight-loss drugs such as orlistat (Xenical), sibutramine (Meridia) and rimonabant experienced only modest weight loss -- less than 11 pounds, which was less than 5 percent of their total body weight. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. 5 or 1 milligram of tesofensine was double that of weight loss seen with the currently available diet drugs Acomplia (rimonabant) or Meridia (sibutramine), the researchers said.

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